Preparation and evaluation of graphene oxide based–materials for anticancer drug delivery in an experimental mice tumor: Thesis Abstract

Thesis Abstract Background: Graphene oxide (GO) is a multifunctional carbon nanomaterial with tremendous potential in medical science including cancer therapy. It has unique physical, and chemical properties to be used as drug carrier such Doxorubicin (DOX). Aim: This study aimed load DOX on supramagnetic iron GO (GO/Fe3O4) passive active forms or without folic acid (FA) compare the anti-tumor effects of these conjugates free DOX.Materials Methods: was synthesized by Hummers method, then loaded DOX, FA Fe3O4. All were characterized FT-IR, TEM TGA techniques, their anticancer investigated vitro using EAC cell lines. In vivo performed EAC-bearing mice which divided treated GO/DOX, rGO/DOX/FA, GO/Fe3O4/DOX, rGO/Fe3O4/FA/DOX, GO/Fe3O4/DOX+IR rGO/Fe3O4/FA/DOX+IR. After 10 days, number tumor cells, splenocytes white blood cells (WBC), apoptosis, cycle analyzed. Results: results showed that induced significant decrease total numbers cells. Interestingly rGO/Fe3O4/FA/DOX+ IR treatment increases late apoptosis whereas GO/DOX rGO/Fe3O4/FA/DOX necrotic compared DOX. Free leukopenia spleen, however GO/FA/DOX lesser effects. Treatment leukocytes GO/DOX/FA leukopenia. Conclusion: These demonstrate composites may highly biocompatible practical applications